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The effects of clinical and statistical heterogeneity on the predictive values of results from meta-analyses  W.G. Melsen, M.C.J. Bootsma, M.M. Rovers,

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Presentation on theme: "The effects of clinical and statistical heterogeneity on the predictive values of results from meta-analyses  W.G. Melsen, M.C.J. Bootsma, M.M. Rovers,"— Presentation transcript:

1 The effects of clinical and statistical heterogeneity on the predictive values of results from meta-analyses  W.G. Melsen, M.C.J. Bootsma, M.M. Rovers, M.J.M. Bonten  Clinical Microbiology and Infection  Volume 20, Issue 2, Pages (February 2014) DOI: / Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 Results of the Monte Carlo simulation study. The associations between the I2-statistic and the probability (%) that the true average relative risk (a) and the result of the reference study (b) are contained in the 95% CI of the meta-analysis, according to different levels of heterogeneity. The dotted line represents the average I2-statistic. The coloured lines represent the probabilities with a fixed-effects model (red) and a random-effects model (blue). MH, calculations based on a fixed-effects model with the Mantel–Haenszel method; RMH, calculations based on a random-effects model with the Mantel–Haenszel method. Clinical Microbiology and Infection  , DOI: ( / ) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 Clinical scenarios.
Clinical Microbiology and Infection  , DOI: ( / ) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions


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