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Multiple Acquired Resistance Mutations of the ALK Tyrosine Kinase Domain after Sequential Use of ALK Inhibitors  Hsin-Yi Wang, MD  Journal of Thoracic.

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Presentation on theme: "Multiple Acquired Resistance Mutations of the ALK Tyrosine Kinase Domain after Sequential Use of ALK Inhibitors  Hsin-Yi Wang, MD  Journal of Thoracic."— Presentation transcript:

1 Multiple Acquired Resistance Mutations of the ALK Tyrosine Kinase Domain after Sequential Use of ALK Inhibitors  Hsin-Yi Wang, MD  Journal of Thoracic Oncology  Volume 12, Issue 5, Pages e49-e51 (May 2017) DOI: /j.jtho Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Time line of treatment. (A) Stepwise emergence of multiple anaplastic lymphoma receptor tyrosine kinase gene (ALK) mutations after sequential anaplastic lymphoma kinase (ALK) inhibitor therapy. (B) Timeline of the treatment course and duration of each ALK inhibitor regimen. The patient received crizotinib, belizatinib, and ceritinib for 9, 4, and 6 months, respectively. (C) Serial brain, chest, and abdominal computed tomography scans during the course of ALK inhibitor therapy. Journal of Thoracic Oncology  , e49-e51DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Resistance analysis of mutations. PE-3314 cells derived from the patient’s pleural effusion collected before death and crizotinib-sensitive A33/R10 lung cancer cells used as control were treated with ceritinib (LDK378) and crizotinib at the indicated concentrations for 96 hours. Cell viability and concentration that inhibits 50% (IC50) were analyzed by using the methyl thiazolyl tetrazolium assay. Cell viability was expressed as a percentage of control for each time point. Error bars are shown as mean plus or minus SD (n = 4). PE-3314 cells carried high resistance to both crizotinib and ceritinib, with IC50 values of 16 μM and 10 μM, respectively. Journal of Thoracic Oncology  , e49-e51DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

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