1. Proteins: Quaternary structure
CHMI 2227E Biochemistry I
Proteins:
Quaternary structure
CHMI E.R. Gauthier, Ph.D.

2. Quaternary structure
CHMI E.R. Gauthier, Ph.D.

3. Quaternary structure hydrophobic hydrophilic
Porin: a trimeric membrane-bound protein
hydrophobic
hydrophilic
CHMI E.R. Gauthier, Ph.D.

4. Quaternary structure Hemoglobin
CHMI E.R. Gauthier, Ph.D.

5. Quaternary structure Hemoglobin HbA vs myoglobin
CHMI E.R. Gauthier, Ph.D.

6. Quaternary structure Oxygen binding by Hb and myoglobin
CHMI E.R. Gauthier, Ph.D.

7. Quaternary structure Oxygen binding by Hb and myoHb
CHMI E.R. Gauthier, Ph.D.

8. Quaternary structure Oxygen binding by Hb and myoHb
CHMI E.R. Gauthier, Ph.D.

9. Quaternary structure Oxygen binding by Hb and myoHb
CHMI E.R. Gauthier, Ph.D.

10. Quaternary structure O2 binding changes the 3-D shape of Hb
CHMI E.R. Gauthier, Ph.D.

11. Quaternary structure O2 binding changes the 3-D shape of Hb
CHMI E.R. Gauthier, Ph.D.

12. Quaternary structure Hb is an allosteric protein
Low affinity
High affinity
Saturated O2
CHMI E.R. Gauthier, Ph.D.

13. Quaternary structure Why Hb is allosteric, while Myoglobin is not?
CHMI E.R. Gauthier, Ph.D.

14. The Bohr effect CHMI 2227 - E.R. Gauthier, Ph.D.
CHMI E.R. Gauthier, Ph.D.

15. Gas exchange In the tissues
Erythrocytes
Glucose + O2
ATP
CO2
H2O
Carbonic
anhydrase
H2CO3
HCO3- H+
Plasma
(to lungs)
Hb-4O2
Hb-H+
4O2
H2O + Cl-
CHMI E.R. Gauthier, Ph.D.

16. Gas exchange In the lungs
CO2
CO2
CO2
H2O
Carbonic
anhydrase
H2CO3
Air
Hb-4O2
H2O + Cl-
HCO3-
HCO3- H+
Hb-H+
4O2 O2 O2
Plasma
Erythrocytes
Lungs
CHMI E.R. Gauthier, Ph.D.