1. Volume 122, Issue 2, Pages 387-393 (February 2002)
5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: A possible role of cysteinyl-leukotrienes 
Mariona Graupera, Juan–Carlos García–Pagán, Esther Titos, Joan Claria, Anna Massaguer, Jaime Bosch, Juan Rodés 
Gastroenterology 
Volume 122, Issue 2, Pages (February 2002)
DOI: /gast
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2. Fig. 1
Cys-LT production in control and CCl4-induced cirrhotic perfused livers. An increased production of Cys-LTs was observed in CCl4-induced cirrhotic livers. Values represent means ± SE. *P < 0.01.
Gastroenterology  , DOI: ( /gast )
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3. Fig. 2
Cys-LTs production was significant and positively correlated with baseline portal PP.
Gastroenterology  , DOI: ( /gast )
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4. Fig. 3
Portal PP dose–response to LTD4 At all tested doses, the increase in PP after LTD4 was significantly greater in CCl4-induced cirrhotic than in control livers. *P < 0.01
Gastroenterology  , DOI: ( /gast )
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5. Fig. 4
Effect on PP of 5-LO inhibition with AA-861 (10 μmol/L) in (A) control and (B) CCl4-induced cirrhotic livers preconstricted with Mtx. 5-LO inhibition produced a significant reduction in PP in both control or cirrhotic livers. Data represent means ± SE. *P < 0.01.
Gastroenterology  , DOI: ( /gast )
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6. Fig. 5
Comparison of the effects of 5-LO inhibition with AA-861 (10 μmol/L) in control (n = 6) and CCl4-induced cirrhotic (n = 10) livers. Reduction of PP after AA-861 was significantly greater in cirrhotic than in control livers.
Gastroenterology  , DOI: ( /gast )
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7. Fig. 6
Effect on PP of MK-571 (1 μmol/L) or AA-861(10 μmol/L) in (A) control and (B) CCl4-induced cirrhotic livers preconstricted with Mtx. In controls, a mild and similar reduction in PP was observed after MK-571 or AA-861. Changes in PP in cirrhotic livers were significantly greater after AA-861 than after MK-571. *P < 0.01
Gastroenterology  , DOI: ( /gast )
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8. Fig. 7
5-LO staining of liver sections from (A, B) control and (C, D) CCl4-induced cirrhotic rats. Sections were incubated with (A, C) PBS–1% BSA as negative control or (B, D) anti–5-LO antiserum. 5-LO–positive cells (open arrows) were markedly increased in CCl4 cirrhotic livers (D) and mainly located along inter nodular septa. Solid arrows indicate autoflurescence of collagen fibers in fibrous septa.
Gastroenterology  , DOI: ( /gast )
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