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Redox Control of Mitochondrial Calcium Uptake

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Presentation on theme: "Redox Control of Mitochondrial Calcium Uptake"— Presentation transcript:

1 Redox Control of Mitochondrial Calcium Uptake
Nicolas Demaurex, Manon Rosselin  Molecular Cell  Volume 65, Issue 6, Pages (March 2017) DOI: /j.molcel Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Oxidation of Cys97 Activates the Mitochondrial Ca2+ Uniporter
Upon oxidative stress, mitochondrial Ca2+ uniporter (MCU) senses mitochondrial ROS production through the oxidation of a matrix-facing cysteine (Cys) residue at position 97. S-glutathionylation of Cys97 induces a conformational change that promotes the clustering of MCU channels and their persistent activation. Sustained mitochondrial Ca2+ uptake decreases respiratory functions and increases mitochondrial ROS levels, leading to mitochondrial [Ca2+] overload-induced cell death. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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