1. What’s Left of Physiology
Sign up for exam day and time & HD survey
Turn in Revised Abstracts
Bio 342 Wofford Course Evaluation
CURE Survey Link in an soon
Test Folders available 2-5 Friday afternoon here in The Pit. No pencils, paper, book.

2. Figure 14.31
Normally, all filtered bicarbonate is “reabsorbed”

3. Diagram respiratory response to:
Vomiting
Diarrhea.

4. % Water Excreted NaCl Excreted Urinalysis Lab 2012 Dilute Salt 77 17
Category
Mean% Excreted
St. Error N=
Difference
Dilute Salt 77 17 14 B
Strong Salt
289 38 18 A
Water
104 9 28
Category
Mean Excreted
St. Error N=
Difference
Dilute Salt
2.0 g
0.2 14
A, B
Strong Salt
2.4 g
0.3 18 A
Water
1.5 g 28 B

5. For 2012, the winner of the Peebody Award produced 1845 ml of urine from 800 ml of water. And the winner is….

6. For 2012, the winner of the The Sahara Award produced a pitiful 0 ml of urine after drinking the “Strong Salt Solution” And the winner is….

7. Filtration is controlled by aa and ea diameters!

8. Consider a substance that in filtered only, no reabsorption, no secretion.
Excretion of this substance = GFR
Clearance of this substance = GFR

9. Clearance = volume of plasma from which a substance is completely removed (cleared) by the kidneys per unit time.
Clearance of Inulin is 120 ml/min
Cinulin or Ccreatinine = Glomerular Filtration Rate

10. Calculating clearance
Clearance of s = Urine concentration of s X Urine Volume
Plasma concentration of s
“24 hour urine catch” + blood sample
Special cases: Clearance of
Inulin and creatinine (filtered only; use to measure Glomerular Filtration Rate.)
Para Amino Hippurate (filtered and completely secreted, use to measure Renal Plasma Flow)

11. Renal Handling of Substances
Filtration + complete Secretion
Ex: Para AminoHippurate (PAH)
Measure Renal Plasma Flow
Filtration + partial reabsorption
Ex: Sodium Ex: Water
Filtration Reabsorption
Ex: Glucose Ex: Amino Acids

12. Clearance of Inulin is 120 ml/min
Clearance = volume of plasma from which a substance is completely removed (cleared) by the kidneys per unit time.
Clearance of Inulin is 120 ml/min
Cinulin or Ccreatinine = Glomerular Filtration Rate
If C x is greater than GFR ( which is Cinulin) then that substance undergoes NET TUBULAR SECRETION
If C x is less than GFR ( which is Cinulin) then that substance undergoes NET TUBULAR REABSORPTION

13. A little more on Clearance:
Clearance of glucose = 0 ml/min which means….
Clearance of X = 120 ml/min which means….
Clearance of antibiotic XXX = 500 ml/min which means…

14. Who Cares?

15. S 17
pp X P?

16. Polycystic Kidney Disease
Fig
Fluid-filled cysts
Polycystic Kidney Disease
Symptoms? Genetics? Prognosis & Treament?
When Ccreatinine = GFR becomes less than 120 ml/min….?
14.04.jpg

17. The End? “Reincarnation” by Wallace McRae