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Mapping MHC-Resident Transplantation Determinants

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Presentation on theme: "Mapping MHC-Resident Transplantation Determinants"— Presentation transcript:

1 Mapping MHC-Resident Transplantation Determinants
Mari Malkki, Ted A. Gooley, Mary M. Horowitz, Lena Absi, Frank T. Christiansen, Jan J. Cornelissen, Anne Dormoy, Valerie Dubois, Katia Gagne, Eliane Gluckman, Michael D. Haagenson, Machteld Oudshoorn, Stephen Spellman, Effie W. Petersdorf  Biology of Blood and Marrow Transplantation  Volume 13, Issue 8, Pages (August 2007) DOI: /j.bbmt Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Physical map of the MHC region and the location of Msat markers used in this study. Position of the Msats and HLA-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, -DQA1, -DQB1, -DPA1, -DPB1, MICA, MICB, and TNF are listed in map order from telomere to centromere on chromosome 6p21.3. Coordinates refer to National Center for Bioinformatics (NCBI) chromosome 6 build 36.2 ( The 3.1-Mb region between HLA-A to HLA-DPB1 is drawn to scale. The genetic distance is 3.6 Mb between D6S276 and D6S105 (single hatch), 2.1 Mb between D6S105 and HLA-A (double hatch), and 3.2 Mb between HLA-DPB1 and D6S291 (triple hatch). The kilobase (kb) pair distance between markers is provided in Table 2. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Rate of mismatching among HLA-A, -B, -C, -DRB1, and -DQB1 matched donor-recipient study pairs for MHC region Msats. HLA loci are included for the purpose of orientation with respect to the Msats studied. Of the 819 study pairs, 704 (86%) were each genotyped for all 12 Msats, 109 (13%) for all Msats except D6S2810, and 6 pairs (3%) for 10 or fewer Msats because of PCR failure. Of the 704 pairs, 11 (1.6%) were matched for all 12 Msat loci; the remaining 693 pairs were mismatched for 1 (1.2%), 2 (2.1%), 3 (2.1%), 4 (6.2%), or 5 or more (86.8%) Msats. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions


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