1. Opioids and neovascularization; pro or anti?
W. Mahbuba, D.G. Lambert 
British Journal of Anaesthesia 
Volume 115, Issue 6, Pages (December 2015)
DOI: /bja/aev357
Copyright © 2015 The Author(s) Terms and Conditions

2. Fig 1
Schematic representation of the possible mechanisms involved in opioid increased angiogenesis. Akt, Protein kinase B (PKB); C-Src, tyrosine kinase; EC, Endothelial cell; EGF, Epidermal growth factor; eNOS, Endothelial nitric oxide synthase; ERK, Extracellular signal-regulated kinases; GDP, Guanosine diphosphate; GP, guanine nucleotide binding protein; HIF-1α, Hypoxia-inducible factor 1-alpha; MAPK, Mitogen-activated protein kinases; PI-3Kinase, Phosphoinositide 3 kinase; PKC, Protein kinase C; RAS, (Rat Sarcoma) protein; Rho/Rho kinase, GTP binding proteinSAPK/JNK, stress-activated protein kinase/c-jun-NH2-kinase; SF, stress fibers; VEGF/R, Vascular endothelial growth factor/receptor.
British Journal of Anaesthesia  , DOI: ( /bja/aev357)
Copyright © 2015 The Author(s) Terms and Conditions