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Efficacy and Toxicity of Idarubicin Versus High-dose Daunorubicin for Induction Chemotherapy in Adult Acute Myeloid Leukemia: A Systematic Review and.

Published byUtami Cahyadi Modified over 6 years ago

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Presentation on theme: "Efficacy and Toxicity of Idarubicin Versus High-dose Daunorubicin for Induction Chemotherapy in Adult Acute Myeloid Leukemia: A Systematic Review and."— Presentation transcript:

1 Efficacy and Toxicity of Idarubicin Versus High-dose Daunorubicin for Induction Chemotherapy in Adult Acute Myeloid Leukemia: A Systematic Review and Meta- analysis  Weerapat Owattanapanich, Natthida Owattanapanich, Smith Kungwankiattichai, Patompong Ungprasert, Theera Ruchutrakool  Clinical Lymphoma, Myeloma and Leukemia  Volume 18, Issue 12, Pages e3 (December 2018) DOI: /j.clml Copyright © 2018 The Authors Terms and Conditions

2 Figure 1 Flowchart Showing the Literature Review Process
Abbreviations: HDD = high-dose daunorubicin; IDA = idarubicin. Clinical Lymphoma, Myeloma and Leukemia  , e3DOI: ( /j.clml ) Copyright © 2018 The Authors Terms and Conditions

3 Figure 2 Forest Plots Showing Odds Ratios Between High-dose Daunorubicin and Idarubicin Arms for the Response to Induction Therapy. (A) Complete Response Rate After First Induction Therapy; (B) Overall Complete Response Rate; and (C) Rate of Refractory Acute Myeloid Leukemia Abbreviations: CI = confidence interval; M-H = Mantel-Haenszel. Clinical Lymphoma, Myeloma and Leukemia  , e3DOI: ( /j.clml ) Copyright © 2018 The Authors Terms and Conditions

4 Figure 3 Forest Plots of Odds Ratios Between High-dose Daunorubicin and Idarubicin Arms for the Long-term Outcomes. (A) Overall Survival, (B) Event-free Survival, and (C) Cumulative Incidence of Relapse Abbreviations: CI = confidence interval; M-H = Mantel-Haenszel. Clinical Lymphoma, Myeloma and Leukemia  , e3DOI: ( /j.clml ) Copyright © 2018 The Authors Terms and Conditions

5 Figure 4 Forest Plots of Odds Ratios Between High-dose Daunorubicin and Idarubicin Arms for Treatment Complications. (A) Rate of Febrile Neutropenia After Induction Therapy; (B) Induction Mortality Rate; and (C) Cardiotoxicity Rate Abbreviations: CI = confidence interval; M-H = Mantel-Haenszel. Clinical Lymphoma, Myeloma and Leukemia  , e3DOI: ( /j.clml ) Copyright © 2018 The Authors Terms and Conditions

6 Supplemental Figure 1 Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement 2009 Checklist Clinical Lymphoma, Myeloma and Leukemia  , e3DOI: ( /j.clml ) Copyright © 2018 The Authors Terms and Conditions

7 Supplemental Figure 1 Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement 2009 Checklist Clinical Lymphoma, Myeloma and Leukemia  , e3DOI: ( /j.clml ) Copyright © 2018 The Authors Terms and Conditions

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