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Eosinophilia in systemic mastocytosis: Clinical and molecular correlates and prognostic significance  Alexandra Böhm, MD, Manuela Födinger, MD, Friedrich.

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Presentation on theme: "Eosinophilia in systemic mastocytosis: Clinical and molecular correlates and prognostic significance  Alexandra Böhm, MD, Manuela Födinger, MD, Friedrich."— Presentation transcript:

1 Eosinophilia in systemic mastocytosis: Clinical and molecular correlates and prognostic significance 
Alexandra Böhm, MD, Manuela Födinger, MD, Friedrich Wimazal, MD, Oskar A. Haas, MD, Matthias Mayerhofer, MD, Wolfgang R. Sperr, MD, Harald Esterbauer, MD, Peter Valent, MD  Journal of Allergy and Clinical Immunology  Volume 120, Issue 1, Pages (July 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Immunohistochemical detection of diagnostic MC infiltrates in a patient with SM-CEL. A bone marrow biopsy section was stained with an antibody against MC tryptase. As can be seen in the figure, compact infiltrates of MCs indicative of the presence of an associated SM were detected in tryptase-stained bone marrow sections. These infiltrates were surrounded and intermingled by infiltrating eosinophils and lymphocytes. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Eosinophil counts and serum tryptase levels in the follow-up period in patients with SM-eo. Absolute eosinophil counts (upper panel) and serum tryptase levels (lower panel) were serially determined in patients with SM-eo during the follow-up period. The initial 42 months of this period, which revealed a relatively constant range for both disease-related parameters, are shown. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Probability of overall survival and event-free survival in patients with SM. In patients (pts) with SM and permanent eosinophilia (SM-eo; n = 9) and those with SM without eosinophilia (n = 54), the probability of overall survival (A) and event-free survival (B) was calculated. The differences were found to be significant (P < .05). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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