Download presentation
Presentation is loading. Please wait.
1
Commanding CNS Invasion: GM-CSF
Junjie Zhao, Lillian Sun, Xiaoxia Li Immunity Volume 46, Issue 2, Pages (February 2017) DOI: /j.immuni Copyright © 2017 Elsevier Inc. Terms and Conditions
2
Figure 1 GM-CSF Drives the Expansion of CNS-Invading Phagocytes
Dysregulated production of GM-CSF by T helper cells induces the expansion of inflammatory monocyte-derived cells (MdCs) in the periphery. The GM-CSF-expanded inflammatory MdCs are capable of producing IL-1β and ROS, which breach the blood-brain barrier and activate the microglia. Activated microglia secrete CCL2 and further recruit the CCR2-expressing inflammatory MCs into the CNS. The infiltrating inflammatory MCs then differentiate into ROS-producing phagocytes, resulting in demyelination and loss of nerve fiber. Immunity , DOI: ( /j.immuni ) Copyright © 2017 Elsevier Inc. Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.