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Commanding CNS Invasion: GM-CSF

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Presentation on theme: "Commanding CNS Invasion: GM-CSF"— Presentation transcript:

1 Commanding CNS Invasion: GM-CSF
Junjie Zhao, Lillian Sun, Xiaoxia Li  Immunity  Volume 46, Issue 2, Pages (February 2017) DOI: /j.immuni Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 GM-CSF Drives the Expansion of CNS-Invading Phagocytes
Dysregulated production of GM-CSF by T helper cells induces the expansion of inflammatory monocyte-derived cells (MdCs) in the periphery. The GM-CSF-expanded inflammatory MdCs are capable of producing IL-1β and ROS, which breach the blood-brain barrier and activate the microglia. Activated microglia secrete CCL2 and further recruit the CCR2-expressing inflammatory MCs into the CNS. The infiltrating inflammatory MCs then differentiate into ROS-producing phagocytes, resulting in demyelination and loss of nerve fiber. Immunity  , DOI: ( /j.immuni ) Copyright © 2017 Elsevier Inc. Terms and Conditions


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