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The Importance of Timing

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1 The Importance of Timing
Richard S. Mann, Clare E. Howard  Cell  Volume 164, Issue 3, Pages (January 2016) DOI: /j.cell Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Temporal Regulation of Proneural Protein Activity
Proneural bHLH proteins are expressed at low levels in proneural clusters. Protein levels increase in one specified neural precursor, while being repressed in neighboring cells. Quan et al. show that, at the peak of expression, proneural proteins are phosphorylated, which prevents DNA binding. This inactivation of proneural bHLH factors is essential for the progression of neurogenesis. Cell  , DOI: ( /j.cell ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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