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Covering the Cover Gastroenterology
Anson W. Lowe, Richard H. Moseley Gastroenterology Volume 150, Issue 1, Pages 1-3 (January 2016) DOI: /j.gastro Copyright © 2016 AGA Institute Terms and Conditions
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Figure 1 Cumulative probability for mesalamine (5-ASA), corticosteroids, immune suppressants, and anti-tumor necrosis factor (TNF) use for Crohn's disease (left) and ulcerative colitis (right) in Asia. Gastroenterology , 1-3DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions
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Figure 2 Meta-analysis of 3 studies that assessed the impact of HCV infection on CVD-related mortality, using the random effects model. ORs and 95% CIs are shown on a logarithm scale. Studies are arranged by publication year. Study names are provided in the corresponding references. Gastroenterology , 1-3DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions
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Figure 3 Depletion of apoE in HCV producer cells efficiently sensitizes HCV virions to antibody-mediated neutralization. Huh7.5.1 cells were either electroporated with VL:JFH1 (A), H77R2a (B) or Luc-Jc1 RNA (C) alone, or co-electroporated with either scrambled siRNA (siCtrl) or siRNA targeting apoE mRNA (siApoE). Neutralization experiments using viruses produced from these cells were performed using sera from 4 different HCV-infected patients (1, 2, 3, or 4) at the indicated dilutions. Infection was determined by end-point dilution assay (A) or luciferase activity (B, C). Mean ± SEM from 7 experiments (A) or 3 experiments performed in duplicate (B, C) are shown. Results are expressed as fold increase of neutralization relative to control serum. ApoE depletion in producer cells was confirmed 72 hours post electroporation by immunoblotting of cell lysates; actin was detected as loading control. ∗P < .05. Gastroenterology , 1-3DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions
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Figure 4 Pancreases derived from PDX-1 KRASG12D (KP) or PDX-1/ ACVR1B/ KRASG12D (AKP) mutant mice with respect to time. (A) Gross specimens. (B) Histology. Gastroenterology , 1-3DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions
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