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Figure 3 Morphologic and molecular analyses of B-cell infiltration and ELS formation in DM Morphologic and molecular analyses of B-cell infiltration and.

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Presentation on theme: "Figure 3 Morphologic and molecular analyses of B-cell infiltration and ELS formation in DM Morphologic and molecular analyses of B-cell infiltration and."— Presentation transcript:

1 Figure 3 Morphologic and molecular analyses of B-cell infiltration and ELS formation in DM
Morphologic and molecular analyses of B-cell infiltration and ELS formation in DM Muscle sections were stained with CD20 to highlight the B-cell content in different DM subgroups (A–D, arrowheads). ELSs showed clear compartmentalization of peripheral CD3+ T cells (E) and CD21+ (F) B cells. The germinal center–like structures consisted of D2-40+ follicular dendritic cells (FDCs) (G), CD23+ B cells (H), MUM1+ B cells (J), and CD31+ HEVs (K) with PAX5+ B cells mainly distributed around them (L). Increased proliferative activity in the B-cell–rich germinal center–like area was indicated by Ki67/MIB1 immunostaining (M). Immunofluorescent labeling demonstrated partial colocalization of central CD20+ B cells with POU2AF1 (BOB-1) (N). (I) mRNA expression of PAX5 and POU2AF1 measured by real-time RT-PCR. The reciprocal ΔCT values are displayed to illustrate levels of gene expression of PAX5 and POU2AF1, genes whose expression was not detectable in ≥2 healthy controls. Results show mean ± SEM. *p < 0.05, **p < DM = dermatomyositis; ELS = ectopic lymphoid structure; mRNA = messenger RNA; RT-PCR = real-time PCR. Josefine Radke et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e451 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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