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Volume 122, Issue 3, Pages (March 2002)

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Presentation on theme: "Volume 122, Issue 3, Pages (March 2002)"— Presentation transcript:

1 Volume 122, Issue 3, Pages 745-751 (March 2002)
Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains  Françoise Dupic, Séverine Fruchon, Mounia Bensaid, Nicolas Borot, Mirjana Radosavljevic, Olivier Loreal, Pierre Brissot, Susan Gilfillan, Siamak Bahram, Hélène Coppin, Marie–Paule Roth  Gastroenterology  Volume 122, Issue 3, Pages (March 2002) DOI: /gast Copyright © 2002 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Effect of strain differences and Hfe genotype on hepatic iron concentration and on the duodenal expression of the Dcytb, DMT1, and FPN1 messengers. The amounts of Dcytb, DMT1, and FPN1 mRNAs were normalized by dividing raw values by the amount of beta-actin mRNA and expressed as the normalized values per 106 beta-actin molecules. Data are presented as mean ± SEM. ***P < ; **P = (when Hfe−/− mice were compared with Hfe+/+ mice of the same genetic background). Gastroenterology  , DOI: ( /gast ) Copyright © 2002 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Simultaneous variations of the Dcytb, DMT1, and FPN1 transcripts in DBA/2 wild-type and knockout mice. The natural logarithm of the transcript quantities were used here to induce normality of the distributions. Simultaneous variations of the transcripts are shown in DBA/2 Hfe+/+ (pyramid) and Hfe−/− (diamond) mice. Gastroenterology  , DOI: ( /gast ) Copyright © 2002 American Gastroenterological Association Terms and Conditions


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