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A New Drug Target for Type 2 Diabetes

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Presentation on theme: "A New Drug Target for Type 2 Diabetes"— Presentation transcript:

1 A New Drug Target for Type 2 Diabetes
Lukas K.J. Stadler, I. Sadaf Farooqi  Cell  Volume 170, Issue 1, Pages (June 2017) DOI: /j.cell Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Current and Potential Treatments for Type 2 Diabetes
(A) Anti-diabetes drugs reduce blood glucose levels by acting at a variety of organs and tissues involved in glucose homeostasis; GLP-1, glucagon-like peptide 1; DPP-4, dipeptidyl peptidase 4; SGLT2, sodium-glucose co-transporter-2. (B) Rusu et al. found that a set of variants in the gene-encoding monocarboxylate transporter 11 (MCT11) impaired cell-surface localization of the protein by reducing its interaction with a chaperone protein, Basigin. Their work suggests that drugs that rescue MCT11 activity could be useful in the treatment of T2D. Cell  , 12-14DOI: ( /j.cell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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