1. TIM-1 Blockade of the Donor Graft Provides Protection Against Lethal Gvhd 
Bettina P. Iliopoulou, PhD, Katie Hsu, MS, Antonio Pierini, MD, Gordon J. Freeman, PhD, Rosemarie H. Dekruyff, PhD, Everett Meyer, MD, PhD 
Biology of Blood and Marrow Transplantation 
Volume 22, Issue 3, Pages S398-S399 (March 2016)
DOI: /j.bbmt
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2. Figure
Antagonistic anti-TIM-1 mAb protects from lethal GVHD. Survival was assessed 70 days post BMT of BALB/c recipient mice treated with lethal body irradiation before receiving allogeneic bone marrow and T cells (Tcon) from C57BL/6 mice. Mice that in addition received five doses (days -1, 3, 7, 11, 15; 400 μg) of the antagonistic anti-TIM-1 mAb (Tcon+BM+3D10 group, n=10) showed a survival advantage (p=0.02) compared to mice that received allogeneic T cells alone (Tcon+BM group, n=10).
Biology of Blood and Marrow Transplantation  , S398-S399DOI: ( /j.bbmt )
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