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Cardiovascular Regeneration: Pushing and Pulling on Progenitors

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Presentation on theme: "Cardiovascular Regeneration: Pushing and Pulling on Progenitors"— Presentation transcript:

1 Cardiovascular Regeneration: Pushing and Pulling on Progenitors
Matthew L. Steinhauser, Richard T. Lee  Cell Stem Cell  Volume 4, Issue 4, Pages (April 2009) DOI: /j.stem Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 Synergism of G-CSF Therapy with Inhibition of Proteolytic Degradation of SDF-1 Results in Progenitor Recruitment to the Heart after Myocardial Infarction (Left) With G-CSF monotherapy, mobilized progenitors do not receive a homing signal to guide migration to the heart. (Right) Inhibition of proteolytic cleavage of SDF-1, in concert with G-CSF therapy, restores progenitor homing. Cell Stem Cell 2009 4, DOI: ( /j.stem ) Copyright © 2009 Elsevier Inc. Terms and Conditions


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