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Figure 3 Transcripts of the splicing mutation (c

Published byIndra Budiaman Modified over 6 years ago

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1 Figure 3 Transcripts of the splicing mutation (c
Figure 3 Transcripts of the splicing mutation (c.174-2A>G) detected by reverse transcription PCR analysis Transcripts of the splicing mutation (c.174-2A>G) detected by reverse transcription PCR analysis A 1.5% agarose gel fractionation of RT-PCR products of blood RNA shows the distinct fragments of cDNA obtained by specific primers. Lane WT represents a normal transcript in a healthy control. Lane MU represents an aberrant transcript in a patient carrying the c.174-2A>G mutation, which contains 3 different bans. Sequencing results show that the band located at 750 bp implies a normal transcript; the band located at 250 bp implies an aberrant transcript, which was caused by exon 6 skipping; and the band located at 500 bp is confirmed to be a result of formation of heterodimer consisting of 1 normal transcript and 1 aberrant transcript. ALS = amyotrophic lateral sclerosis; cDNA = complementary DNA; FTD = frontotemporal lobe dementia; RT-PCR = reverse transcription PCR. Kang Zhang et al. Neurol Genet 2018;4:e237 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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