1. Left Ventricular Fibrosis and Systolic Hypertension Persist in a Repaired Aortic Coarctation Model 
Jie Liu, PhD, Douglas Drak, BSc, Anish Krishnan, BSc, Sing-Young Chen, BSc, Carla Canniffe, MD, PhD, Shisan Bao, PhD, Gareth Denyer, PhD, David S. Celermajer, MD, PhD 
The Annals of Thoracic Surgery 
Volume 104, Issue 3, Pages (September 2017)
DOI: /j.athoracsur
Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

2. Fig 1
Effects of 3 weeks of transverse aortic constriction (TAC) compared with sham operation. Graphs show (A) systolic blood pressure and diastolic blood pressure. (B) Maximum left ventricular (LV) pressure and (C) heart chamber mass indexed by tibial length. Note that both atria were measured together. Data are shown as mean + SEM; **p < 0.01; ***p < compared with sham.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

3. Fig 2
Comparison of sham operated, repaired, and unrepaired animals at 25 weeks after the repair operation. Graphs show (A) aortic pressure proximal to the constriction site, (B) the systolic blood pressure (SBP) gradient between the ascending and abdominal aorta, (C) maximum left ventricular (LV) pressure, and (D) heart chamber mass indexed to tibial length. Note that the left and right atria were weighed together. Data are shown as mean + standard error of the mean (SEM); *p < 0.05; ***p < compared with sham; ###p < compared with repaired.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

4. Fig 3
Hematoxylin and eosin staining of tissue sections from the left ventricle. Representative images from each experimental group are shown. Graph shows group means + standard error of mean (SEM); ***p < compared with sham; ###p < compared with repaired.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

5. Fig 4
Picrosirius red stain shows deposition of collagen (red) in the left ventricle. Representative images from each experimental group are shown. Graph shows group means + standard error of mean (SEM); ***p < compared with sham; ###p < compared with repaired.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

6. Fig 5
Changes in gene expression 25 weeks after repair. The quantitative real-time polymerase chain reaction (qRT-PCR) results of genes differentially expressed, as identified by microarray. All graphs show mean number of gene transcripts per 1 million copies of 18S rRNA + standard error of mean (SEM). For natriuretic peptide A (NPPA), natiuretic peptide B (NPPB), calsequestrin 1 (CASQ1) and connective tissue growth factor (CTGF): n = 5 for sham, n = 7 for unrepaired, and n = 6 for repaired. Statistical significance was assessed by Mann-Whitney test. For actin alpha 1 (ACTA1) and myosin heavy chain alpha (MYH6): n = 5 for sham, n = 7 for unrepaired, and n = 5 for repaired. For ankyrin repeat domain 23 (ANKRD23) and sulfotransferase family 1A member 1 (SULT1A1): n = 5 for sham, n = 7 for unrepaired, and n = 6 for repaired. For flavin containing monooxygenase 2 (FMO2): n = 5 for sham, n = 7 for unrepaired, and n = 5 for repaired; *p < 0.05; **p < 0.01 compared with sham; #p < 0.05; ##p < 0.01 compared with repaired.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions