1. Enhancing a sedation score to include truly noxious stimulation: the Extended Observer's Assessment of Alertness and Sedation (EOAA/S) 
T.K. Kim, P.J. Niklewski, J.F. Martin, S. Obara, T.D. Egan 
British Journal of Anaesthesia 
Volume 115, Issue 4, Pages (October 2015)
DOI: /bja/aev306
Copyright © 2015 The Author(s) Terms and Conditions

2. Fig 1
The predicted propofol effect-site concentrations vs observed EOAA/S scores. The lines, symbols, and colours for each subject are arbitrarily alternating for clarity. EOAA/S, Extended Observer's Assessment of Alertness and Sedation. Ce, predicted effect site concentration; 0T, unresponsiveness to trapezius squeeze; 0E, unresponsiveness to tetanic stimulation. See Table 1 for more detailed explanation of the EOAA/S.
British Journal of Anaesthesia  , DOI: ( /bja/aev306)
Copyright © 2015 The Author(s) Terms and Conditions

3. Fig 2
Propofol predicted effect-site concentration vs the observed EOAA/S scores presented as a bubble plot. The area of each bubble is proportional to the number of subjects (n) receiving the specified EOAA/S score at the specified propofol concentration target. The solid vertical lines represent the pharmacodynamic model Ce50 estimates for the EOAA/S sedation scores of less than or equal to four. The vertical dotted lines indicate the pharmacodynamic model Ce50 estimates after brief transcutaneous electrical stimulation (TES). Unresponsiveness to trapezius squeeze is denoted as 0T; unresponsiveness to TES is denoted as 0E. The Ce50,s values are the pharmacodynamic model estimates of the propofol concentrations associated with a 50% probability that the EOAA/S score would be equal to or less than the specified score. EOAA/S, Extended Observer's Assessment of Alertness and Sedation, Ce, predicted effect site concentration.
British Journal of Anaesthesia  , DOI: ( /bja/aev306)
Copyright © 2015 The Author(s) Terms and Conditions

4. Fig 3
The probability of each EOAA/S score as a function of predicted propofol effect site concentration according to the pharmacodynamic model. Unresponsiveness to trapezius squeeze is denoted as 0T; unresponsiveness to TES is denoted as 0E. P, probability; EOAA/S, Extended Observers Assessment of Alertness and Sedation; Ce, predicted effect site concentration.
British Journal of Anaesthesia  , DOI: ( /bja/aev306)
Copyright © 2015 The Author(s) Terms and Conditions

5. Fig 4
Logistic regression models predicting the probability of specified EOAA/S scores with the corresponding Ce50s. Ce50 is defined in the text. Unresponsiveness to trapezius squeeze is denoted as 0T; unresponsiveness to TES is denoted as 0E. EOAA/S, Extended Observers Assessment of Alertness and Sedation; Ce, predicted effect site concentration.
British Journal of Anaesthesia  , DOI: ( /bja/aev306)
Copyright © 2015 The Author(s) Terms and Conditions