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Rifaximin Is Safe and Well Tolerated for Long-term Maintenance of Remission From Overt Hepatic Encephalopathy  Kevin D. Mullen, Arun J. Sanyal, Nathan.

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Presentation on theme: "Rifaximin Is Safe and Well Tolerated for Long-term Maintenance of Remission From Overt Hepatic Encephalopathy  Kevin D. Mullen, Arun J. Sanyal, Nathan."— Presentation transcript:

1 Rifaximin Is Safe and Well Tolerated for Long-term Maintenance of Remission From Overt Hepatic Encephalopathy  Kevin D. Mullen, Arun J. Sanyal, Nathan M. Bass, Fred F. Poordad, Muhammad Y. Sheikh, R. Todd Frederick, Enoch Bortey, William P. Forbes  Clinical Gastroenterology and Hepatology  Volume 12, Issue 8, Pages e2 (August 2014) DOI: /j.cgh Copyright © 2014 AGA Institute Terms and Conditions

2 Figure 1 Rates of HE-related and all-cause hospitalizations for the all-rifaximin and new-rifaximin populations in the OLM compared with patients receiving historical placebo or rifaximin in the 6-month RCT. *P < vs placebo. Inferential statistics were not conducted for the all-rifaximin and new-rifaximin populations. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions

3 Supplementary Figure 1 CONSORT flow diagram. aThe integrated safety population (all-rifaximin population, N = 392) included the new-rifaximin population plus all patients who received rifaximin during the RCT regardless of enrollment into the OLM (gray shaded boxes). CONSORT, Consolidated Standards of Reporting Trials. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions

4 Supplementary Figure 2 Antibiotic use time in the all-rifaximin population. Clinical Gastroenterology and Hepatology  , e2DOI: ( /j.cgh ) Copyright © 2014 AGA Institute Terms and Conditions


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