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Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung  Hyo Sup Shim, MD, PhD, Mari- Kenudson, MD, Zongli Zheng,

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Presentation on theme: "Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung  Hyo Sup Shim, MD, PhD, Mari- Kenudson, MD, Zongli Zheng,"— Presentation transcript:

1 Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung 
Hyo Sup Shim, MD, PhD, Mari- Kenudson, MD, Zongli Zheng, PhD, Matthew Liebers, BSc, Yoon Jin Cha, MD, Quan Hoang Ho, BSc, Maristela Onozato, MD, PhD, Long Phi Le, MD, PhD, Rebecca S. Heist, MD, MPH, A. John Iafrate, PhD  Journal of Thoracic Oncology  Volume 10, Issue 8, Pages (August 2015) DOI: /JTO Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Mutation distribution for 30 mucinous adenocarcinomas that underwent NGS. All 30 cases were previously determined to be KRAS wild type by targeted methodology. NGS, next generation sequencing. Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Pie charts showing the fraction of mucinous adenocarcinomas that harbor the indicated drivers (A) and the fraction of subtypes of KRAS mutations (B). Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Scatter dot plots for total mutation count between two groups defined by mucinous histology (A), TP53 mutation (B), and smoking status (C) in TCGA lung adenocarcinoma. TCGA, The Cancer Genome Atlas. Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Distribution of mutation counts in TCGA lung adenocarcinoma. Mucinous adenocarcinomas (red) and TP53-mutant cases (blue) are indicated. EGFR-mutant cases (enriched in nonsmokers), KRAS-mutant cases (enriched in smokers), and ALK/ROS1/RET fusions (enriched in nonsmokers) are included as a validation of the data set. TCGA, The Cancer Genome Atlas. Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

6 FIGURE 5 Survival curves comparing mucinous and nonmucinous cases for overall (A) and recurrence-free (B) survival in stage I–IIIA. Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

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