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Cancer Genomes Evolve by Pulverizing Single Chromosomes

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Presentation on theme: "Cancer Genomes Evolve by Pulverizing Single Chromosomes"— Presentation transcript:

1 Cancer Genomes Evolve by Pulverizing Single Chromosomes
Matthew Meyerson, David Pellman  Cell  Volume 144, Issue 1, Pages 9-10 (January 2011) DOI: /j.cell Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Stitching Together Shattered Chromosomes by Chromothripsis
Chromothripsis is proposed to involve the shattering of a single chromosome, a small group of chromosomes, or a single chromosome arm. The fragments, or a subset of the fragments, are then stitched together by nonhomologous end-joining. The mechanism by which these alterations are confined to a small segment of the genome is not defined. Cell  , 9-10DOI: ( /j.cell ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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