1. The lymphoid liver: Considerations on pathways to autoimmune injury
Hiroto Kita, Judy Van De Water, M.Eric Gershwin 
Gastroenterology 
Volume 120, Issue 6, Pages (May 2001)
DOI: /gast
Copyright © 2001 American Gastroenterological Association Terms and Conditions

2. Fig. 1
Immunologic components of the liver. The liver should be considered a lymphoid organ based not only on the properties of hepatocytes, but also on constituent cell populations. There are 2 separate regions of the liver depicted, the (A) sinusoid and the (B) portal tract, illustrating the interrelationship between the hepatic and the immune constituents.
Gastroenterology  , DOI: ( /gast )
Copyright © 2001 American Gastroenterological Association Terms and Conditions

3. Fig. 2
Potential mechanisms of immune-mediated damage in AIH. To date, there is no known immunologic basis for cellular injury in AIH, although autoantibodies have been implicated through an ADCC- or C'-mediated pathway. The involvement of T cells is still highly speculative.
Gastroenterology  , DOI: ( /gast )
Copyright © 2001 American Gastroenterological Association Terms and Conditions

4. Fig. 3
Potential mechanisms of bile duct damage in PBC. The exact pathway of immune-mediated tissue destruction in PBC is unknown, however, it has been suggested that PDC-E2–specific IgA may be involved during the normal course of transcytosis. Additional possibilities include NKT-mediated ADCC and/or CD8+ CTL-mediated damage.
Gastroenterology  , DOI: ( /gast )
Copyright © 2001 American Gastroenterological Association Terms and Conditions

5. Fig. 4
Little is known about the role of the immune system in the periductular fibrosis and eventual destruction of bile ducts in PSC. CD8+ T cells have been shown to be present in the portal tract of PSC liver, however, no antigen specificity has been shown for these cells. There is the suggestion of a link between PSC and inflammatory bowel disease with respect to the influence of cytokines on the bile ducts. There is no known role for the humoral immune system in the pathology of PSC.
Gastroenterology  , DOI: ( /gast )
Copyright © 2001 American Gastroenterological Association Terms and Conditions