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“The Very Pulse of the Machine”: The Tuberculous Granuloma in Motion

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Presentation on theme: "“The Very Pulse of the Machine”: The Tuberculous Granuloma in Motion"— Presentation transcript:

1 “The Very Pulse of the Machine”: The Tuberculous Granuloma in Motion
J. Muse Davis, Lalita Ramakrishnan  Immunity  Volume 28, Issue 2, Pages (February 2008) DOI: /j.immuni Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Stages of BCG Granuloma Formation in the Mouse Liver
Upon infection, blood-borne bacteria are phagocytosed by resident Kupffer cells. At 2 weeks after infection, infected Kupffer cells have attracted local resident macrophages and monocyte-derived macrophages. Arriving T lymphocytes are also seen. By 3 weeks after infection, T cells are plentiful among the macrophages. T cells migrate in constant contact with a “scaffold” of macrophages. Immunity  , DOI: ( /j.immuni ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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