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Osteopontin-Expressing Macrophages in Non-Small Cell Lung Cancer Predict Survival  Yue Li, MD, Bing-sheng Sun, MD, PhD, Baoxiang Pei, MD, Chen-guang Li,

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Presentation on theme: "Osteopontin-Expressing Macrophages in Non-Small Cell Lung Cancer Predict Survival  Yue Li, MD, Bing-sheng Sun, MD, PhD, Baoxiang Pei, MD, Chen-guang Li,"— Presentation transcript:

1 Osteopontin-Expressing Macrophages in Non-Small Cell Lung Cancer Predict Survival 
Yue Li, MD, Bing-sheng Sun, MD, PhD, Baoxiang Pei, MD, Chen-guang Li, MD, Zhen-fa Zhang, MD, PhD, Yue-song Yin, MD, Chang-li Wang, MD, PhD  The Annals of Thoracic Surgery  Volume 99, Issue 4, Pages (April 2015) DOI: /j.athoracsur Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Typical expression images of CD34 immunohistochemistry for microvessel density in tissue microarrays. CD34+, ×40. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 (A) Double immunofluorescence staining for CD68 and osteopontin (OPN); immunolocalization of OPN (green) and CD68 (red) frequently overlap (yellow) (×400); (B) Immunolocalization of OPN (green), CD68 (red), which frequently overlap (yellow), and 4′,6-diamidino-2-phenylindole (blue) (×100). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Prognostic significance assessed using Kaplan-Meier survival estimates and log-rank tests. (A, C) Comparisons of overall survival and (B, D) disease-free survival by (A, B) tumor-associated macrophages (TAMs) and (C, D) osteopontin expressed by tumor-associated macrophages (TOPN). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Kaplan-Meier analysis of (A) overall survival and (B) disease-free survival for osteopontin expressed by tumor-associated macrophages TOPN in non-small cell lung carcinoma patients of stage I. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions


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