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Dominant allele with recessive lethality (black) Dominant allele with recessive lethality.

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Presentation on theme: "Dominant allele with recessive lethality (black) Dominant allele with recessive lethality."— Presentation transcript:

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4 Dominant allele with recessive lethality
(black) Dominant allele with recessive lethality

5 Dominant allele with recessive lethality
1 gene with 2 alleles we’ve seen 4 cases: Dominant allele with recessive lethality 1 AA : 2 Aa : 1 aa complete dom/rec dom dom rec incomplete dominance dom blend dom-rec rec codominant dom dom1+ dom dom2 recessive lethal (dom. marker) dead dom rec

6 IC. Genes with multiple alleles
1 Gene with 3 alleles IA & IB are co-dominant; i is recessive

7 IC. Genes with multiple alleles
Hierarchy of dominance: C > cch > ch > c

8 IC. Genes with multiple alleles
chinchilla cch

9 IC. Genes with multiple alleles
chinchilla cch

10 IC. Genes with multiple alleles
chinchilla cch himalayan ch

11 IC. Genes with multiple alleles
Hierarchy of dominance: C > cch > ch > c

12 IC. Genes with multiple alleles

13 IC. Genes with multiple alleles
A short list of the 1587 known mutant alleles of the Drosophila melanogaster eye color gene w (white)

14 ID. Two genes, interacting
Back to 2 genes TIME

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18 ID. Two genes, interacting

19 A/A ; B/B a/a ; b/b A/a ; B/b self-cross

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22 ww m+ & m

23 Coat color: Genes A, B, C, D, E, S

24 A

25 AY

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27 B

28 cc C

29 C

30 C

31 D

32 E e

33 E e

34 ee B & b

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36 cc B & b

37 Agouti, not Yellow (A, not AY)

38 cc A & a

39 cc A & a

40 Genotype ratios: 1:2:1:2:4:2:1:2:1
(“A” here =AY) X X X X Phenotype ratios: 9:3:3:1 Genotype ratios: 1:2:1:2:4:2:1:2:1 AYAY X X X CC:Cc:cc 6:3:3

41 Hair color genes- - A, B, C, D, E & … S

42 II. Mention epistasis versus suppression

43 Genotype -> Phenotype
III. Genotype -> Phenotype . . . but with interactions of unknown other genes, environment,

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48 Lack of Penetrance Variable Expressivity Lack of Penetrance

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