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Dominant allele with recessive lethality
(black) Dominant allele with recessive lethality
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Dominant allele with recessive lethality
1 gene with 2 alleles we’ve seen 4 cases: Dominant allele with recessive lethality 1 AA : 2 Aa : 1 aa complete dom/rec dom dom rec incomplete dominance dom blend dom-rec rec codominant dom dom1+ dom dom2 recessive lethal (dom. marker) dead dom rec
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IC. Genes with multiple alleles
1 Gene with 3 alleles IA & IB are co-dominant; i is recessive
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IC. Genes with multiple alleles
Hierarchy of dominance: C > cch > ch > c
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IC. Genes with multiple alleles
chinchilla cch
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IC. Genes with multiple alleles
chinchilla cch
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IC. Genes with multiple alleles
chinchilla cch himalayan ch
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IC. Genes with multiple alleles
Hierarchy of dominance: C > cch > ch > c
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IC. Genes with multiple alleles
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IC. Genes with multiple alleles
A short list of the 1587 known mutant alleles of the Drosophila melanogaster eye color gene w (white)
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ID. Two genes, interacting
Back to 2 genes TIME
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ID. Two genes, interacting
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A/A ; B/B a/a ; b/b A/a ; B/b self-cross
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ww m+ & m
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Coat color: Genes A, B, C, D, E, S
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A
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AY
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B
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cc C
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C
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C
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D
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E e
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E e
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ee B & b
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cc B & b
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Agouti, not Yellow (A, not AY)
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cc A & a
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cc A & a
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Genotype ratios: 1:2:1:2:4:2:1:2:1
(“A” here =AY) X X X X Phenotype ratios: 9:3:3:1 Genotype ratios: 1:2:1:2:4:2:1:2:1 AYAY X X X CC:Cc:cc 6:3:3
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Hair color genes- - A, B, C, D, E & … S
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II. Mention epistasis versus suppression
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Genotype -> Phenotype
III. Genotype -> Phenotype . . . but with interactions of unknown other genes, environment,
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Lack of Penetrance Variable Expressivity Lack of Penetrance
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