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Preoperative predictors of postsurgical adhesion formation and the Prevention of Adhesions with Plasminogen Activator (PAPA-study): results of a clinical.

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Presentation on theme: "Preoperative predictors of postsurgical adhesion formation and the Prevention of Adhesions with Plasminogen Activator (PAPA-study): results of a clinical."— Presentation transcript:

1 Preoperative predictors of postsurgical adhesion formation and the Prevention of Adhesions with Plasminogen Activator (PAPA-study): results of a clinical pilot study  Bart W.J. Hellebrekers, M.D., Ph.D., Trudy C.M. Trimbos-Kemper, M.D., Ph.D., Lianne Boesten, Ph.D., Frank Willem Jansen, M.D., Ph.D., Wendela Kolkman, M.D., Ph.D., J. Baptist Trimbos, M.D., Ph.D., Rogier R. Press, Pharm.D., Mariette I.E. van Poelgeest, M.D., Ph.D., Sjef J. Emeis, Ph.D., Teake Kooistra, Ph.D.  Fertility and Sterility  Volume 91, Issue 4, Pages (April 2009) DOI: /j.fertnstert Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Mean preoperative plasma levels of CRP in patients with and without adhesions (yes vs. no) at early second-look laparoscopy (ESL). Mann-Whitney U test: rs = 0.471; P=.027; n = 23). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Correlation between the change in tissue-type plasminogen activator (tPA) concentration (ΔtPA) in peritoneal fluid from initial surgery to early second-look laparoscopy (ESL) and extent of adhesion formation (cm2) confined to the uterus at ESL (Spearman rho: rs = −0.636; P=.001; n = 22). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Mean change in tissue-type plasminogen activator (tPA) concentration (ΔtPA) in peritoneal fluid from initial surgery to ESL in patients with and without adhesions (yes vs. no) at early second-look laparoscopy (ESL). (Mann-Whitney U test: rs = −0.561; P=.01; n = 22). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

5 Figure 4 Postoperative course of concentrations in plasma of fibrinolytic parameters and C-reactive protein (CRP) after myomectomy (values are median). ∗time points that were significantly different from baseline values (P<.05, analysis of variance for repeated measures). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions


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