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Off-Pump Coronary Artery Bypass Reduces Early Stroke in Octogenarians: A Meta- Analysis of 18,000 Patients  Salah E. Altarabsheh, MD, Salil V. Deo, MS,

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Presentation on theme: "Off-Pump Coronary Artery Bypass Reduces Early Stroke in Octogenarians: A Meta- Analysis of 18,000 Patients  Salah E. Altarabsheh, MD, Salil V. Deo, MS,"— Presentation transcript:

1 Off-Pump Coronary Artery Bypass Reduces Early Stroke in Octogenarians: A Meta- Analysis of 18,000 Patients  Salah E. Altarabsheh, MD, Salil V. Deo, MS, MCh, Abeer M. Rababa'h, PhD, Ju Yong Lim, MD, Yang Hyun Cho, MD, Vikas Sharma, MD, Sung Ho Jung, MD, Euisoo Shin, MD, Alan H. Markowitz, MD, Soon J. Park, MD  The Annals of Thoracic Surgery  Volume 99, Issue 5, Pages (May 2015) DOI: /j.athoracsur Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Flow chart depicting study selection for meta-analysis.
(Adapted from Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med 6:e ) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 The pooled result demonstrates that patients undergoing off-pump coronary artery bypass grafting (OPCABG) had a significantly fewer number of grafts than did patients in the on-pump CABG (ONCABG) cohort (mean difference, –0.52 [–0.83 to –0.20]). (CI = confidence interval; SD = standard deviation.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 (A) Funnel plot demonstrating publication bias. (B) Adjusted Forest plot of pooled result for early mortality using the trim-fill method. (RR = risk ratio; seTE = standard error for treatment estimate; TE = treatment estimate.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 (A) Funnel plot demonstrates publication bias for the analysis of stroke (p = 0.01). (B) The adjusted Forest plot demonstrates that off-pump coronary artery bypass grafting (OPCABG) has a lower stroke risk than on-pump CABG (ONCABG). (RR = risk ratio; seTE = standard error for treatment estimate; TE = treatment estimate.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 (A) Forest plot for respiratory failure demonstrates that off-pump coronary artery bypass grafting (OPCABG) is better than on-pump CABG (ONCABG). (B) Cumulative meta-analysis demonstrates that the resultant heterogeneity (I2 ) is caused by adding Cavallaro and colleagues to the pooled result. (RR = risk ratio.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

7 Fig 6 Forest plot for postoperative atrial fibrillation demonstrates that rates are comparable in both cohorts (p = 0.27). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

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