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Inherited Germline T790M Mutation and Somatic Epidermal Growth Factor Receptor Mutations in Non-small Cell Lung Cancer Patients  Carmelo Tibaldi, MD,

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Presentation on theme: "Inherited Germline T790M Mutation and Somatic Epidermal Growth Factor Receptor Mutations in Non-small Cell Lung Cancer Patients  Carmelo Tibaldi, MD,"— Presentation transcript:

1 Inherited Germline T790M Mutation and Somatic Epidermal Growth Factor Receptor Mutations in Non-small Cell Lung Cancer Patients  Carmelo Tibaldi, MD, Elisa Giovannetti, MD, PhD, Enrico Vasile, MD, Laura Boldrini, MD, PhD, Marielle I. Gallegos-Ruiz, MD, Ilaria Bernardini, MD, Roberto Incensati, MD, Romano Danesi, Prof, Federico Cappuzzo, MD, Godefridus J. Peters, Prof, Gabriella Fontanini, Prof  Journal of Thoracic Oncology  Volume 6, Issue 2, Pages (February 2011) DOI: /JTO.0b013e a6f Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 A, Pedigree of a family with cases of non-small cell lung cancers. B, Representative electropherogram for EGFR sequencing of the samples of the proband (sample #1) and her sister (sample #2). Sample #1 and #2 harbored a T790M mutation that was read from both the forward and reverse sequence. The figure also includes a positive control. Furthermore, the analysis included a sample with a known wild-type sequence at position 790, and a negative control (water), which was negative, excluding the chance of contamination. C, Representative electropherogram of the deletion E746-A750 (ELREA) in EGFR exon 19 (panel B) in comparison with the wild-type sequence (panel A), as detected in the tumor tissue of the proband. EGFR, epidermal growth factor receptor. Journal of Thoracic Oncology 2011 6, DOI: ( /JTO.0b013e a6f) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

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