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Updates on the Prevention and Management of CINV

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Presentation on theme: "Updates on the Prevention and Management of CINV"— Presentation transcript:

1 Updates on the Prevention and Management of CINV

2 Topics Covered

3 Types of CINV

4 Emetogenic Potential of Regimens

5 Patient-Related Risk Factors

6 Why It Is Important to Prevent CINV

7 What Does Prophylaxis Involve?

8 Therapies for Preventing or Treating CINV

9 Clinical Practice Guidelines for Preventing and Managing CINV

10 MASCC Recommendations for Preventing Acute Nausea and Vomiting

11 MASCC Recommendations for Delayed Nausea and Vomiting

12 Challenges: Nonadherence to Practice Guidelines

13 Clark-Snow et al Findings

14 More Recently Approved Therapies

15 Rolapitant: Schwartzberg et al

16 Rolapitant: Schwartzberg et al (cont)

17 Rolapitant: Rapoport et al

18 Rolapitant: Navari et al

19 Rolapitant: Aapro et al

20 NEPA: Approval

21 NEPA: Gralla et al Phase 3 Trial

22 NEPA: Aapro et al Phase 3 Trial

23 NEPA: Feyer et al

24 NEPA: Aapro et al Post Hoc Safety Analysis

25 Palonosetron in Triplet Regimen

26 Palonosetron in Triplet Regimen (cont)

27 Aprepitant: Kang et al

28 Kang et al: CR Rate

29 Olanzapine: Navari et al

30 Navari et al Study Findings

31 Navari et al Study Findings (cont)

32 Olanzapine: Chiu et al

33 APF530: A New 5-HT3 RA Formulation

34 Updated Clinical Practice Guidelines

35 Updated ASCO Guidelines

36 Summary of Key Points

37 Abbreviations

38 Abbreviations (cont)


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