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Complete Radiological Response of Metastatic Anaplastic Lymphoma Kinase-Positive Signet Ring Lung Adenocarcinoma to Systemic Chemotherapy  Grzegorz Korpanty,

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Presentation on theme: "Complete Radiological Response of Metastatic Anaplastic Lymphoma Kinase-Positive Signet Ring Lung Adenocarcinoma to Systemic Chemotherapy  Grzegorz Korpanty,"— Presentation transcript:

1 Complete Radiological Response of Metastatic Anaplastic Lymphoma Kinase-Positive Signet Ring Lung Adenocarcinoma to Systemic Chemotherapy  Grzegorz Korpanty, MD, PhD, Niall Mulligan, MD, Desmond N. Carney, MD, PhD  Journal of Thoracic Oncology  Volume 6, Issue 5, Pages (May 2011) DOI: /JTO.0b013e318215a242 Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Chest x-ray examination at presentation (A, anteroposterior [AP] view; B, right lateral view) showed bulky right-sided hilar mass, consolidation in the right lower lung zone with ipsilateral pleural effusion. Journal of Thoracic Oncology 2011 6, DOI: ( /JTO.0b013e318215a242) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Bronchioalveolar lavage (BAL) sample cytology showed malignant cells with signet ring features (A). Transbronchial biopsy of right hilar mass was consistent with signet ring adenocarcinoma (B; insert, ×200 magnification; hematoxylin and eosin [HE] staining) that was positive on immunohistochemistry for lung cancer-specific marker, TTF-1 (3+) (C). anaplastic lymphoma kinase (ALK) protein expression (2+) was confirmed by immunohistochemistry (D). Journal of Thoracic Oncology 2011 6, DOI: ( /JTO.0b013e318215a242) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Whole body positron emission tomography (PET)/computed tomography (CT) scan post four cycles of systemic chemotherapy with carboplatin and pemetrexed showed remarkable radiological response within the right hilar and mediastinal lymphadenopathy (A, F), right lung base tumor (B, G), liver mass (C, D, H, and I), and retroperitoneal lymphadenopathy on the right (E, J). Journal of Thoracic Oncology 2011 6, DOI: ( /JTO.0b013e318215a242) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

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