1. Spineless Behavior of CX3CR1+ Monocytes in Response to Infection
Paul A. Muller, Daniel Mucida 
Immunity 
Volume 47, Issue 1, Pages (July 2017)
DOI: /j.immuni
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
Poly(I:C)-Induced CX3CR1+ Monocyte-Derived TNF-α Leads to Cortical Dendritic Spine Loss and Negatively Impacts Memory Formation
On the left (highlighted in blue), a wild-type mouse is trained on an accelerating rotating rod (rotarod). Following a 2-day training period, longitudinal two-photon microscopy reveals an increase in motor cortex neuronal dendritic spines as indicated by the blue arrows. At the right (highlighted in red), a wild-type mouse is injected with the viral mimetic polyinosinic-polycytidilic acid (poly(I:C)) prior to rotarod training. After the same 2-day training period, there is a decrease in the number of dendritic spines as indicated by the red arrows. In addition, the mouse shows a significant impairment in the ability to recall a recent motor memory, which is illustrated by a failure to stay on the rotarod. The decrease in spine number and memory impairment is likely the result of TNF-α secreted by CX3CRhi circulating monocytes in response to poly(I:C).
Immunity  , 12-14DOI: ( /j.immuni )
Copyright © 2017 Elsevier Inc. Terms and Conditions