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Monoclonal Antibodies
The use of monoclonal antibodies in enabling the targeting of specific substances and cells. Starter: Write down everything you know about antibodies
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Antibodies Y
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Monoclonal Antibodies
Combining a B cell that can recognize a particular antigen and a long-lived myeloma cell makes the resulting hybridoma cell a long-lasting, antibody-making factory. Because the antibodies made are all identical clones made from a single (mono) hybridoma cell, they are called monoclonal antibodies
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Targeting specific substances – pregnancy test
hCG: hormone produced by embryo Antibodies bound to a coloured dye (beads) If hCG present, binds to form an a-a complex Carries dye with it, so strip turns blue If no hCG, no a-a complex forms, so strip stays same
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Targeting specific cells - cancer treatment
Monoclonal antibodies can be used to treat cancer two ways: Triggering the body’s immune system to attack the cancer cell and can cause the cell to kill itself Attaching a cancer drug to the antibody
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