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Benefit of different concentrations of intralesional triamcinolone acetonide in alopecia areata: An intrasubject pilot study Thomas Waitao Chu, MD, Mohammed AlJasser, MD, FRCPC, Aymen Alharbi, MD, Othman Abahussein, MD, Kevin McElwee, PhD, Jerry Shapiro, MD, FRCPC Journal of the American Academy of Dermatology Volume 73, Issue 2, Pages (August 2015) DOI: /j.jaad Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions
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Fig 1 Alopecia areata (AA). Hair growth response to different concentrations of intralesional triamcinolone acetonide (TA). A 3- × 3-cm patch of AA was divided into quadrants with tattoo marks for reference. Each quadrant was randomly assigned 2.5, 5, or 10 mg/mL TA or normal saline (NS) control. Each quadrant received the same TA concentration for 6 intralesional injections at 6-week intervals. The patches were photographed pretreatment (A) and at 42 weeks, after 6 treatment sessions (B). Hair growth responses in terms of density (P < .025) and caliber (P < .04) were observed in scalp skin receiving 2.5, 5, or 10 mg/mL TA, relative to NS control. Among the triamcinolone-injected quadrants there was no significant difference in the 5- and 10-mg/mL concentrations compared with the 2.5-mg/mL concentration. Journal of the American Academy of Dermatology , DOI: ( /j.jaad ) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions
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Fig 2 Hair density (HD) response to different concentrations of intralesional triamcinolone acetonide (TA) for alopecia areata (AA). For each patient (N = 4), 2.5, 5, or 10 mg/mL TA in normal saline (NS) or NS placebo was injected into randomly assigned quadrants of AA patches on visit 1 and subsequent visits 2 to 6. HD was normalized by same-subject measurements from non-AA-affected scalp areas at visit 1. Change in HD was assessed at subsequent visits 2 through 7, and the changes in mean HD for each concentration are shown. Significant increase in HD (P < .025) over time was observed with 2.5, 5, or 10 mg/mL TA, but not with NS. However, there was no significant difference in the 5- and 10-mg/mL treated quadrants compared with the 2.5-mg/mL treated quadrant. Journal of the American Academy of Dermatology , DOI: ( /j.jaad ) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions
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