1. Device for controllable administration of drug dosage
Graduation Project I
Device for controllable administration of drug dosage
Prepared By:
- Mona Ibrahim
- Azza Al Hassani
- Asma Ahmed
- Hamda Al Ketbi
- Moza Al Shamsi
Adviser’s name:
- Dr. Yousef Haik

2. Presentation Layout Motivation Objectives Design Process
Testing Device
Dispensing Device
Communication Device
Conclusion

3. Motivation

4. Project Description
Dispensing Device
Testing Device
Physician
Patient

5. Blood Clotting
A natural process in which blood cells and fibrin strands clump together to stop bleeding

6. Blood Coagulation Mechanism

7. Prothrombin Time (PT) The time it takes plasma to clot.
PT is reported in seconds

8. International Normalization Ratio (inr)
The ratio of the patient's clotting time to the mean reference value.

9. Anticoagulants Medications that delay the coagulation of blood
Some of these are:
Heparin
Argatroban
Hirudin
Warfarin

10. Warfarin the most widely used oral anticoagulant.
It is a non-habit forming medication.
to prevent formation of new blood clots in high-risk patients

11. Motivation Frequent Monitoring Dose adjustment Reduce patient error
Time saving
Availability of a patient medical history
Reduce visitation to clinic.

12. Objectives Design a blood testing mechanism
Design a drug dispensing mechanism
Design and construct a working prototype of the system
Dispensing Device
Testing Device
Physician
Patient

13. Design Process
Gantt Chart

14. The Harmony INR Monitoring System
Market Analysis
The ProTime
System-PT-
INR
Testing
The Harmony INR Monitoring System
Coaguchek
System
INRatio®PT
Monitoring
System

15. Function Structure Global device function Overall function structure
Drug dose
Blood sample
System
Blood Sample
Testing Device
Dispenser
Communicator
INR value
Dose
Drug Dosage
Hold Sample
Overall function structure

16. Specifications
Measuring Device
Dispensing Device

17. Measuring Device Touch button operation Small sample volume: 20 µL
Portable and easy to use
Large, easy to read reporting screen
Durable
Repeatable
Cost effective meter and test strip
Dimension 5"×3"
Small sample volume: 20 µL
Perform measurement automatically as soon as the sample is applied
Measuring time is less than one minute
Sensitive: can measure less than 1 mg/mL of Prothrombin
Made of biocompatible materials
Disposable sample holder
Meet the International Biomedical Instrumentation standards

18. Dispensing Device Store medicine Cost effective
Dispense one tablet at the time
Time for dispensing to be less than 2 minutes
Patient interference to the device is negligible
Cost effective
Durable
Dimension 5”×2.5”
Safe, no sharp corner

19. Communication Device Cost effective
Dimension 5”×3”
Communication between the medical doctor and the device within one day
The whole device dimension should not exceed 26.5"×12"

20. Developing concepts

21. Testing Morphological Chart
Hold Sample
Testing methods
1.RLC
2. Protein separation
3. Contact angle
4. Plasma profile
5. Viscosity
6. Light intensity
7. Shear stress
8.Charged
Particle
9.Elisa
10.Cantilever beam
11.Piezoelectric
12. Blood layer thickness
Display INR
Digital display
Printer
LED monitor
LCD

22. Testing Methods
1. RLC Testing Method

23. Experiments
Measuring the capacitance across the copper plates with time

24. experiments
Measuring the capacitance across the copper plates with time for different INR values (adding tissue factor)

25. Contact angle Method

26. Contact angle measurements
Result
θ is too small
to measure
Syringe
camera
sample stage
light source
Measure
surface area
Captive Bubble Contact Angle apparatus

27. Surface Area method

28. Protein Separation Method

29. viscosity Method
Resistance measurements
Charged particle Method

30. Shear stress
Measuring the distance moved

31. Light intensity
Blood layer thickness

32. Cantilever beam Method Plasma profile Method
More

33. viscosity Method

34. Charged particle Method+ -
Function Generator

35. piezoelectric Method
Flow in pipes

36. Drug dispensing device

37. dispenser Morphological Chart
Tablet Holder
Mover
Belt
Shaft
Gear
Pulleys
Manual
Rollers
Piston

38. dispenser Morphological Chart
Actuator
Dc motor
pneumatic
hydraulic
Step motor
count
IR sensor
Laser Sensor
Distance Sensor
Lock
solenoid
Worm gear
Spring damping
Spring solenoid arm locking
(hook)

39. dispenser Morphological Chart
Cutter
cutter
Scissors
(Sharp)
Paper cutter
Utility Knife
Ejector

40. Dispensing concept 1

41. Dispensing concept 2

42. Dispensing concept 3

43. Dispensing concept 4

44. Dispensing concept 5

45. Communication device

46. communication Morphological Chart
Sending signals
Wire
modem
Sound
Fiber optic
Laser
transmitter

47. Cost estimation

48. The budget

49. Testing device

50. Dispensing device

51. Communication part

52. Experimental part

53. CONCLUSION

54. FUTURE WORK Resuming investigating the testing methods
Evaluating testing methods to select the proper one
Analyzing the design of testing, dispensing, and communication
Building a prototype for the whole device
Experiments

55. Tasks

56. GANTT CHART