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The Effect of Folinic Acid on Methylenetetrahydrofolate Reductase Polymorphisms in Methotrexate-Treated Allogeneic Hematopoietic Stem Cell Transplants 

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Presentation on theme: "The Effect of Folinic Acid on Methylenetetrahydrofolate Reductase Polymorphisms in Methotrexate-Treated Allogeneic Hematopoietic Stem Cell Transplants "— Presentation transcript:

1 The Effect of Folinic Acid on Methylenetetrahydrofolate Reductase Polymorphisms in Methotrexate-Treated Allogeneic Hematopoietic Stem Cell Transplants  Nicholas M. Murphy, Mary Diviney, Jeff Szer, Peter Bardy, Andrew Grigg, Rosemary Hoyt, Belinda King-Kallimanis, Rhonda Holdsworth, James McCluskey, Brian D. Tait  Biology of Blood and Marrow Transplantation  Volume 18, Issue 5, Pages (May 2012) DOI: /j.bbmt Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 The hazard/odds ratio of clinical outcomes influenced by the donor MTHFR 677 genotypes. (A) Patients not provided with FA rescue; (B) patients provided with FA rescue; (C) Kaplan-Meier graph of the first day that a manifestation of GVHD was observed; (D) Kaplan-Meier graph of the incidence of survival following transplantation. Significant associations are indicated by the hazard/odds ratio and its respective confidence interval both <1 for a lower risk of events occurring or >1 for a higher risk of events occurring. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 The hazard/odds ratio of clinical outcomes influenced by the patient MTHFR 677 genotypes. (A) Patients not provided with FA rescue; (B) patients provided with FA rescue; (C) Kaplan-Meier graph of the first day that a manifestation of GVHD was observed; (D) Kaplan-Meier graph of the incidence of survival following transplantation. Significant associations are indicated by the hazard/odds ratio and its respective confidence interval both <1 for a lower risk of events occurring or >1 for a higher risk of events occurring. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 The hazard/odds ratio of clinical outcomes influenced by the donor MTHFR 1298 genotypes. (A) Patients not provided with FA rescue; (B) patients provided with FA rescue; (C) Kaplan-Meier plot of EFS; (D) Kaplan-Meier plot of overall survival following transplantation. Significant associations are indicated by the hazard/odds ratio and its respective confidence interval both <1 for a lower risk of events occurring or >1 for a higher risk of events occurring. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 The hazard/odds ratio of clinical outcomes influenced by the patient MTHFR 1298 genotypes. (A) Patients not provided with FA rescue; (B) patients provided with FA rescue; (C) Kaplan-Meier graph of the incidence of opiate use; (D) Kaplan-Meier plot of the incidence of total parenteral nutrition use. Significant associations are indicated by the hazard/odds ratio and its respective confidence interval both <1 for a lower risk of events occurring or >1 for a higher risk of events occurring. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions


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