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Loss of tumor cell CCR4 expression upon leukemic change in adult T-cell leukemia/lymphoma  Kazunari Sugita, MD, Takatoshi Shimauchi, MD, Rieko Kabashima,

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Presentation on theme: "Loss of tumor cell CCR4 expression upon leukemic change in adult T-cell leukemia/lymphoma  Kazunari Sugita, MD, Takatoshi Shimauchi, MD, Rieko Kabashima,"— Presentation transcript:

1 Loss of tumor cell CCR4 expression upon leukemic change in adult T-cell leukemia/lymphoma 
Kazunari Sugita, MD, Takatoshi Shimauchi, MD, Rieko Kabashima, MD, Daiki Nakashima, MD, Ryosuke Hino, MD, Kenji Kabashima, MD, Motonobu Nakamura, MD, Yoshiki Tokura, MD  Journal of the American Academy of Dermatology  Volume 61, Issue 1, Pages (July 2009) DOI: /j.jaad Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 A, Initial presentation in January B, Histology of the skin tumor. C, Immunohistochemical staining for CD4. D, Recurrent tumors in August E, Splenic involvement with tumor cells (September 2007). (B and E, Hematoxylin–eosin stain; original magnification: B, C, and E, ×200.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 A and B, Flow cytometry of peripheral blood mononuclear cells and tumor-infiltrating cells during the nonleukemic phase in January C, Peripheral blood mononuclear cells and subcutaneous and spleen cells (D) after the leukemic conversion in September They were double-stained with the indicated monoclonal antibodies. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

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