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Clindamycin vs. first-generation cephalosporins for acute osteoarticular infections of childhood-a prospective quasi-randomized controlled trial H. Peltola, M. Pääkkönen, P. Kallio, M.J.T. Kallio Clinical Microbiology and Infection Volume 18, Issue 6, Pages (June 2012) DOI: /j x Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions
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FIG. 1 Flow chart. Randomization was performed by contacting a special ward of the Children's Hospital (Helsinki, Finland). A computer-generated number was given by telephone. Quasi-randomization was performed by birth date. Children born on an odd day were given clindamycin; children with an even birthday received first-generation cephalosporin. Clinical Microbiology and Infection , DOI: ( /j x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions
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FIG. 2 Normalization of the serum C-reactive protein (CRP) level (± standard error of the mean) and erythrocyte sedimentation rate (ESR) and of white blood cell (WBC) count occurred almost identically in the clindamycin and cephalosporin groups. The small difference in the CRP levels on day 3 (105 mg/L in the cephalosporin group and 87 mg/L in the clindamycin group) remained non-significant (p 0.13 by t-test). Clinical Microbiology and Infection , DOI: ( /j x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions
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