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Rapid onset of CD8+ aggressive T-cell lymphoma during bexarotene therapy in a patient with Sézary syndrome  Alexander Kreuter, MD, Peter Altmeyer, MD 

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Presentation on theme: "Rapid onset of CD8+ aggressive T-cell lymphoma during bexarotene therapy in a patient with Sézary syndrome  Alexander Kreuter, MD, Peter Altmeyer, MD "— Presentation transcript:

1 Rapid onset of CD8+ aggressive T-cell lymphoma during bexarotene therapy in a patient with Sézary syndrome  Alexander Kreuter, MD, Peter Altmeyer, MD  Journal of the American Academy of Dermatology  Volume 53, Issue 6, Pages (December 2005) DOI: /j.jaad Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Immunohistologic stainings at first presentation (CD4+ cells, 80% positive [A]; CD8+ cells, 10% positive [B]). Immunohistologic transformation after 6 months of bexarotene therapy (CD4+ cells, 0% positive [C]; CD8+ cells, 90% positive [D]). (A and C, CD4 stain, original magnification ×40; B and D, CD8 stain, original magnification ×40.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Rapid onset of subcutaneous tumors (tumor masses filling complete left cheek [A]; multiple nodules, 1-5 cm in diameter, mostly located on back and chest [B]). Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

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