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Surfactant function in lung transplantation after 24 hours of ischemia: Advantage of retrograde flush perfusion for preservation  Martin Strüber, MDa,

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Presentation on theme: "Surfactant function in lung transplantation after 24 hours of ischemia: Advantage of retrograde flush perfusion for preservation  Martin Strüber, MDa,"— Presentation transcript:

1 Surfactant function in lung transplantation after 24 hours of ischemia: Advantage of retrograde flush perfusion for preservation  Martin Strüber, MDa, Jens M. Hohlfeld, MDb, Theo Kofidis, MDa, Gregor Warnecke, MDa, Jost Niedermeyer, MDb, Sebastian P. Sommer, MSa, Axel Haverich, MDa  The Journal of Thoracic and Cardiovascular Surgery  Volume 123, Issue 1, Pages (January 2002) DOI: /mtc Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

2 Fig. 1 PO2/FIO2 of miniature pigs before single lung transplantation (basal) and after 0.5 to 7 hours of reperfusion after single lung transplantation and clamping of the contralateral lung. Grafts were preserved with LPD solution by antegrade versus retrograde flush perfusion and stored for 24 hours. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

3 Fig. 2 Dynamic lung compliance 0.5 to 7 hours after single left lung transplantation and clamping of the contralateral lung. Grafts were preserved with LPD solution by antegrade versus retrograde flush perfusion and stored for 24 hours. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

4 Fig. 3 Extravascular lung water index 0.5 to 7 hours after single left lung transplantation and clamping of the contralateral lung. Grafts were preserved with LPD solution by antegrade versus retrograde flush perfusion and stored for 24 hours. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

5 Fig. 4 Minimal surface tension of the BAL fluid in milli-Newtons per meter, as determined with a bubble surfactometer. Results are shown before flush perfusion of the right lung (basal) and after 2 hours of reperfusion of the transplanted left lung. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

6 Fig. 5 SA/LA ratio of BAL fluid. Results are shown before flush perfusion of the right lung (basal) and after 2 hours of reperfusion of the transplanted left lung. A significant increase P =.037) was found after reperfusion (2 hours) in the antegrade group. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

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