1. Chemical-Induced Naive Pluripotency
Angela J. Russell, Laurence Silpa 
Cell Chemical Biology 
Volume 23, Issue 5, Pages (May 2016)
DOI: /j.chembiol
Copyright © 2016 Elsevier Ltd Terms and Conditions

2. Figure 1 Production of Embryonic and Epiblast Stem Cells.
Naive pluripotent mouse ESCs and primed pluripotent mouse EpiSCs can be derived from pre-implantation blastocysts and post-implantation epiblasts, respectively. Both pluripotent cell types have, in principle, the capacity to differentiate to cells representative of the three primary germ layers and ultimately into the cell types in embryonic and adult tissues. Epiblastin A, a recently discovered CK1 inhibitor, was found to reprogram mouse EpiSCs refractory to other treatments to a naive pluripotent state.
Cell Chemical Biology  , DOI: ( /j.chembiol )
Copyright © 2016 Elsevier Ltd Terms and Conditions