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The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome

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Presentation on theme: "The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome"— Presentation transcript:

1 The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome
Cailyn H. Spurrell, Diane E. Dickel, Axel Visel  Cell  Volume 167, Issue 5, Pages (November 2016) DOI: /j.cell Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Lineage-Specific Interactions of Promoters with Non-coding Regulatory Sequences (Left) Javierre et al. (2016) used promoter capture Hi-C (PCHi-C) to systematically map interactions between promoters and promoter-interacting regions (PIRs) across 17 primary human hematopoietic cell types (10 representative examples shown). (Right) Comparison of PIR-promoter interactions across cell types reveals that some interactions are invariant across all cell types examined, while others are specific to major lineages or individual cell types. Importantly, some promoters interact with different sets of PIRs depending on cell type, and vice versa, some PIRs interact with different sets of promoters in a cell-type-specific manner. Cell  , DOI: ( /j.cell ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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