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Figure 1 Effect of DMF therapy on T cell subsets

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Presentation on theme: "Figure 1 Effect of DMF therapy on T cell subsets"— Presentation transcript:

1 Figure 1 Effect of DMF therapy on T cell subsets
Effect of DMF therapy on T cell subsets Peripheral blood mononuclear cells from 12 patients with relapsing-remitting multiple sclerosis (RRMS) at baseline (0M) and after 6 months of therapy (6M) with dimethyl fumarate (DMF; Tecfidera, Biogen, Weston, MA) were thawed and analyzed by flow cytometry for changes in the T cell compartment. (A) Left: CD3+CD56− T cells as percentage of total lymphocytes; right: ratio of CD4+ to CD8+ T cells. (B) DMF-induced changes in CD8+ T cells (top left: CD8+CD4− T cells as percentage of total T cells; top center: CD8+CD45RO− naive T cells as percentage of total CD8+ T cells; top right: CD8+CD45RO+ memory T cells as percentage of total CD8+ T cells) and in CD4+ T cells (bottom left: CD4+CD8− T cells as percentage of total T cells; bottom center: CD4+CD45RO− naive T cells as percentage of total CD4+ T cells; bottom right: CD4+CD45RO+ memory T cells as percentage of total CD4+ T cells). Statistical analysis was done by paired Student t test, *p < 0.05, **p < 0.01, ***p < Catharina C. Gross et al. Neurol Neuroimmunol Neuroinflamm 2016;3:e183 © 2015 American Academy of Neurology

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