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Robin L. Holland, Steven R. Blanke  Cell Host & Microbe 

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1 Dynamic Intervention: Pathogen Disarmament of Mitochondrial-Based Immune Surveillance 
Robin L. Holland, Steven R. Blanke  Cell Host & Microbe  Volume 16, Issue 5, Pages (November 2014) DOI: /j.chom Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Recognition of Pathogens by Host Cell Surveillance
(A) Schematic drawing of Vibrio cholerae disarmament of mitochondrial immune surveillance through the T3SS effector VopE resulting in inhibition of mitochondrial perinuclear clustering and immune activation. (B) Models of pathogen recognition by host cell surveillance machinery. PAMP recognition: results in indiscriminate recognition of pathogens and commensals. DAMP recognition: results in time-dependent, indiscriminate response to cell death. Guard hypothesis: results in specific recognition of pathogens and not commensal microbes. Cell Host & Microbe  , DOI: ( /j.chom ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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