1. The Negative Regulator CXXC5: Making WNT Look a Little Less Dishevelled 
Dongwon Kim, Luis A. Garza 
Journal of Investigative Dermatology 
Volume 137, Issue 11, Pages (November 2017)
DOI: /j.jid
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2. Figure 1
Model proposed by Lee et al. (2017). When WNT3a binds to receptors (Frizzled and LRP5/6), the receptor complex recruits Dvl to inhibit AXIN, APC, and GSK3β, resulting in accumulating stabilized b-catenin to exert its function as a co-factor of TCF and LEF for gene expression. One of WNT/β-catenin induced genes is CXXC5 which functions as a negative regulator by interacting with Dvl. CXXC5 is highly expressed in human alopecia patients and might be upregulated by PGD2 and DHT in male pattern baldness. As a clinical approach, short peptide inhibitor which targets CXXC5-Dvl interactions can be a promising strategy for therapy of hair loss patients. APC, adenomatosis polyposis coli; CXXC5, CXXC5-type zinc finger protein 5; DHT, dihydrotestosterone; Dvl, dishevelled; GSK3β, glycogen synthase 3β; LEF, lymphoid enhancing factor; LRP5/6, low-density lipoprotein receptor-related protein 5/6; PGD2, prostaglandin G2; TCF, transcription factor.
Journal of Investigative Dermatology  , DOI: ( /j.jid )
Copyright © 2017 The Authors Terms and Conditions