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Fig. 5 Analysis of metabolite changes in M

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1 Fig. 5 Analysis of metabolite changes in M
Fig. 5 Analysis of metabolite changes in M. smegmatis after treatment with the GSK compound GSK A. Analysis of metabolite changes in M. smegmatis after treatment with the GSK compound GSK A. (A) Pairwise similarity between M. smegmatis metabolome response profiles to 16 GSK compounds with no similarity to known MoAs. (B) Schematic representation of trehalose monomycolate exporter protein MmpL3. Transmembrane segments are represented in violet. Circles indicate the locations of amino acid changes associated with resistance of M. tuberculosis to antimycobacterial lead compounds previously found to select for resistance mutations in MmpL3. These compounds include SQ109 (blue), THPP (orange), and SPIROS (purple). The black star indicates the amino acid change associated with resistance to the GSK compound GSK A. The genomes of the M. tuberculosis H37Rv and Beijing GC1237 mutant strains contain an A to G SNP at position 755, which resulted in a tyrosine to cysteine missense mutation at position 252 of the MmpL3 protein. (C) Results from limited proteolysis analysis. Each dot in the volcano plot represents the relative difference in peptide abundance between the treated and untreated proteome extracts. Proteins highlighted in red are known to physically interact with fatty acid synthase FAS-I (figs. S17 and S18). For each protein, the size of the dot reflects the number of interacting partners (80) with significant conformational changes. (D) Rapid metabolic changes induced by the GSK antimicrobial compound GSK A. Each dot corresponds to the R2 and Z-score values of the metabolite 5 min after exposure of M. smegmatis to the antimicrobial compound. Metabolites highlighted in red are involved in fatty acid metabolism. Mattia Zampieri et al., Sci Transl Med 2018;10:eaal3973 Published by AAAS

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