1. AMACING
Trial design: Patients with chronic kidney disease undergoing intravascular iodinated contrast administration were randomized to prophylactic hydration (n = 328) vs. no hydration (n = 332).
Results
(p = 0.47)
Contrast-induced nephropathy: 2.7% of the hydration group vs. 2.6% of the no hydration group (p = 0.47)
All-cause mortality: 0 vs. 0.9%, for hydration vs. no hydration (p = 0.13)
Symptomatic heart failure: 4.0% vs. 0, for hydration vs. no hydration (p = ) %
2.7
2.6
Conclusions
Among patients with chronic kidney disease undergoing intravascular contrast administration, no hydration was noninferior to prophylactic hydration
Prophylactic hydration was associated with a higher frequency of symptomatic heart failure episodes vs. no hydration
Hydration
No hydration
Nijssen EC, et al. Lancet 2017;389: