1. Turning Gray: The Natural History of Lung Cancer Over Time
Frank C. Detterbeck, MD, Christopher J. Gibson, BA 
Journal of Thoracic Oncology 
Volume 3, Issue 7, Pages (July 2008)
DOI: /JTO.0b013e31817c9230
Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

2. FIGURE 1
Survival of 23,954 patients with NSCLC who did not receive surgical resection, chemotherapy or radiotherapy.36
Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e31817c9230)
Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

3. FIGURE 2
Mean doubling times observed among human non-small cell lung cancers, by the method of detection.
Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e31817c9230)
Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

4. FIGURE 3
Proportion of patients with very short (<100 days) or very long (≥400 days) tumor doubling times according to the method of lung cancer detection.
Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e31817c9230)
Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

5. FIGURE 4
Proportion of tumor doubling time categories by radiographic appearance among CT screen detected cancers. A, Hasegawa M, et al. Br J Radiol 2000;73:1252–59;16 B, Sone S, et al. Lung Cancer 2007;58:329–41;18 C, Lindell RM, et al. Radiology 2007;242:555–62;17 VDT: volume doubling time.
Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e31817c9230)
Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

6. FIGURE 5
Schematic of exponential growth of a cancer, with time expressed as number of volume doublings. (From Geddes DM. Br J Dis Chest 1979;73:1–17.34)
Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e31817c9230)
Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

7. FIGURE 6
Gomperztian growth curve demonstrated by observed average growth rates in 100 mice after implantation of adenocarcinoma. The solid and dotted line represents a best-fit Gompertz function. (From Schabel FM. Cancer 1975;35:15–24.28)
Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e31817c9230)
Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions